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排序方式: 共有1624条查询结果,搜索用时 140 毫秒
51.
Yusuke Nakajima Takeshi Kawano Yusuke Taki Chie Kojima 《Research on Chemical Intermediates》2018,44(8):4745-4754
Collagen is a major component of the extracellular matrix, and collagen gels have been used as cell scaffolds. We previously prepared gold nanoparticle (AuNP)-embedded collagen gels (AuCol) to serve as cell scaffolds that were sensitive to visible light. We performed single cell detachment from this cell scaffold using a microscope equipped with a laser irradiation system. In the present study, we adjusted hydrogel thickness and AuNP concentration in AuCol, with a goal of improving cell detachment efficiency. Thin hydrogels became blackened after the laser irradiation, and thick hydrogels with high AuNP concentrations were not permeable to the laser light. We, therefore, prepared bilayer gels, composed of AuCol as the upper layer and intact collagen gel (Col) as the bottom layer. These bilayer gels allowed more effective cell detachment, because they were thick and optically transparent. Our results indicated that an AuCol/Col ratio of 2 enabled the highest cell detachment efficiency. Essentially, no cell damage was observed in our system, suggesting that this is a cell-friendly single cell separation system. 相似文献
52.
Masato Nagata 《Meccanica》2016,51(12):3015-3023
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Boon-Teck Heng Wan Ahmad Kamil Mahmood Teruo Shinomiya Nozomi Uchida Masato M. Ito 《Liquid crystals》2013,40(2):204-215
Two series of new Cu(II) complexes derived from the reaction of copper acetate with the non-linear 1,2,3-triazole-based Schiff bases have successfully been synthesised. The structures of the ligands and its complexes were elucidated by elemental analysis, FT-IR, 1H-NMR and UV–visible spectroscopic techniques. The differential scanning calorimetry and polarizing optical microscopy supported the anisotropic properties of uncoordinated ligands in which the focal conic fan-shaped texture and/or broken fan-shaped texture characteristics of respective SmA and SmC phases were recorded. However, not all of their corresponding Cu(II) complexes are mesogenic. Although the iodo-substituted ligands with even parity C10H29 to C14H33 are non-stable and exhibit SmA phase which is not reproducible, the ultimate Cu(II) complexes show exclusively stable SmA phase. This observation can be ascribed to the enhanced colinearity and molecular anisotropic by the presence of Cu-N and Cu-O coordination modes. On the other hand, the comparison studies show that different positions of ortho-hydroxyl group affect the mesomorphic and thermal behaviour of ligands and Cu(II) complexes. 相似文献
54.
Stereoselective analysis of flecainide enantiomers using reversed‐phase liquid chromatography for assessing CYP2D6 activity 下载免费PDF全文
Kosuke Doki Yukio Sekiguchi Keisuke Kuga Kazutaka Aonuma Yukinao Kohda Masato Homma 《Biomedical chromatography : BMC》2014,28(9):1193-1198
Stereoselective analyses of flecainide enantiomers were performed using reversed‐phase high‐performance liquid chromatography (HPLC) equipped with a polysaccharide‐based chiral column (Chiralpak AS‐RH) and fluorescence detector. Excitation and emission wavelengths were set at 300 and 370 nm, respectively. Flecainide enantiomers in serum and urine were extracted using diethyl ether. The mobile phase solution, comprising 0.1 m potassium hexafluorophosphate and acetonitrile (65:35, v/v), was pumped at a flow rate of 0.5 mL/min. The recoveries of flecainide enantiomers were greater than 94%, with the coefficients of variation (CVs) <6%. The calibration curves of flecainide enantiomers in serum and urine were linear in the concentration range 5–500 ng/mL and 0.75–15 µg/mL (r > 0.999), respectively. CVs in intra‐day and inter‐day assays were 1.8–5.8 and 3.4–7.5%, respectively. In a pharmacokinetic study, the ratios of (S)‐ to (R)‐flecainide (S/R ratio) in the area under the curve and the amount of flecainide enantiomers excreted in urine were lower in a subject carrying CYP2D6*10/*10 than in subjects carrying CYP2D6*1/*2. The S/R ratio of trough serum flecainide concentration ranged from 0.79 to 1.16 in patients receiving oral flecainide. The present HPLC method can be used to assess hepatic flecainide metabolism in a pharmacokinetic study and therapeutic drug monitoring. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
55.
We generalize the author’s formula (2011) on weighted counting of inversions on permutations to one on alternating sign matrices. The proof is based on the sequential construction of alternating sign matrices from the unit matrix which essentially follows from the earlier work of Lascoux-Schützenberger (1996).
相似文献56.
Type I (α-) and II cleavages are two of the best known photochemical processes of alkanone.2 Extensive and intensive investigations have been done on both types of reactions in order to clarify the influence of structural changes on the reactivity, specificity, and efficiency of photoreactions of alkanones.3 The type I cleavage of medium-ring alkanones is believed to produce a radical pair, the fate of which will be determined by the ready formation of transition states for transfer of Ha, Hb, and recyclization. We now wish to report 相似文献
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59.
Prof. Joe Otsuki Takumi Okumura Dr. Kosuke Sugawa Dr. Shin-ichiro Kawano Prof. Kentaro Tanaka Dr. Takehiro Hirao Prof. Takeharu Haino Yu Jin Lee Seongsoo Kang Prof. Dongho Kim 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(12):4053-4063
Self-assembly of porphyrins is a fascinating topic, not only for mimicking chlorophyll assemblies in photosynthetic organisms, but also for the potential of creating molecular-level devices. Herein, zinc porphyrin derivatives bearing a meta-pyridyl group at the meso position were prepared and their assemblies studied in chloroform. Among the porphyrins studied, one with a carbamoylpyridyl moiety gave a distinct 1H NMR spectrum in CDCl3, which allowed the supramolecular structure in solution to be probed in detail. Ring-current-induced chemical-shift changes in the 1H NMR spectrum, together with vapor-pressure osmometry and diffusion-ordered NMR spectroscopy, among other evidence, suggested that the porphyrin molecules form a trimer with a triangular cone structure. Incorporation of a directly linked porphyrin–ferrocene dyad with the same assembling properties in the assemblies led to a rare example of a light-harvesting/charge-separation system in which an energy gradient is incorporated and reductive quenching occurs. 相似文献
60.
Highly selective acylation of the alcoholic hydroxy group can be achieved with (hydroxyalkyl)phenols carrying both alcoholic and phenolic hydroxyls by the use of the most common acylating agents, acid chlorides, under microwave irradiation. 相似文献